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Longitudinal prediction of BMI using explainable AI: integrating polygenic scores, maternal, early-life and familial factors - International Journal of Obesity
1+ hour, 45+ min ago (1717+ words) International Journal of Obesity (2026)Cite this article This study aimed to predict body mass index (BMI) trajectories from childhood to early adulthood using explainable artificial intelligence, integrating adult BMI polygenic scores (PGS), maternal, early-life, and familial factors to identify key…...
Diagnostic accuracy, fairness and clinical implementation of AI for breast cancer screening: results of multicenter retrospective and prospective technical feasibility studies - Nature Cancer
6+ day, 11+ hour ago (1589+ words) Nature Cancer (2026)Cite this article The retrospective evaluation covered five breast screening services from across the UK, representing three distinct clinical workflows, including 125,000 women aged 5070, who were screened in 20152016, as summarized in Table 1. The final analysis included 115,973 women after applying…...
Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer metastasis - Nature Communications
1+ mon, 1+ week ago (1719+ words) All animal procedures were performed with approval from the Institutional Animal Care and Use Committee at Baylor College of Medicine (Protocol number AN-7145). For human sample analysis, de-identified blood samples from breast cancer patients were obtained after receiving their informed…...
Finger-prick transcriptomic profiling in northern Nigeria reveals a muted maternal systemic response in stillbirth - npj Women's Health
1+ mon, 2+ week ago (1054+ words) npj Women's Health volume4, Articlenumber:8 (2026) Cite this article RNA yield and quality metrics from the 50l Minivette protocol are summarized in Table 1. The RNA concentrations ranged from 2 to 26ng/l, with integrity values between 5.5 and 8.0. All samples met the established quality assurance thresholds,…...
Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade - Cell Death & Differentiation
1+ mon, 2+ week ago (185+ words) Cell Death & Differentiation (2026)Cite this article This work was supported in part by grands from, and grands from the National Natural Science Foundation of China (82403715, 82270585, 42125707, 82400655 and U25A201), Natural Science Foundation of Chongqing (CSTB2024NSCQ-LZX0067), Major State Basic Research Development Program of China (2022YFA1103402), and…...
Maternal inheritance of primary sex ratios in the dark-winged fungus gnat Lycoriella ingenua - Heredity
1+ mon, 2+ week ago (1685+ words) Heredity (2026)Cite this article Changes in sex ratio biases across generations were examined by categorising broods as male-biased (>0.6), unbiased (0.40.6), and female-biased ( To determine whether there was an effect of temperature on the sex ratio, a linear regression model was used,…...
Bisphosphate nucleotidase 1 promotes progression and docetaxel resistance in triple-negative breast cancer via STUB1-mediated destabilization of LIMA1 - Cell Death & Disease
2+ mon, 1+ day ago (1817+ words) Cell Death & Disease volume17, Articlenumber:40 (2026) Cite this article Human TNBC cell lines, MCF10A, and HEK293T were obtained from the Shanghai Key Laboratory of Breast Cancer (FUSCC) and authenticated by short tandem repeat profiling (STR). MCF10A cells were cultured as described in published protocols [29], while…...
A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID - npj Women's Health
2+ mon, 2+ day ago (1630+ words) npj Women's Health volume4, Articlenumber:3 (2026) Cite this article Both ME/CFS and long COVID participants must meet the National Institute for Health and Care Excellence (NICE) guidelines for ME/CFS, which recommend considering a diagnosis if the following symptoms have persisted…...
Neonatal outcomes following maternal red cell transfusions prior to or at delivery - Journal of Perinatology
2+ mon, 4+ day ago (646+ words) Journal of Perinatology (2026)Cite this article Anemia affects up to one-third of pregnant women and has been associated with adverse maternal and neonatal outcomes [1, 2]. However, little is known about the impact of maternal red cell (RBC) transfusions. The objective of…...
The role of the SLC25A15 transporter in the formation of liver metastasis in ESR1-mutated breast cancer
2+ mon, 1+ week ago (371+ words) Oncogene (2026)Cite this article Receive 50 print issues and online access only $5.18 per issue The datasets used and/or analyzed during the current study are available from the corresponding authors on reasonable request. Merenbakh-Lamin K, Ben-Baruch N, Yeheskel A, Dvir A,…...