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The pathophysiology of pre-eclampsia - Nature Reviews Nephrology
9+ hour, 55+ min ago (1677+ words) Nature Reviews Nephrology (2026) Cite this article Pre-eclampsia is defined as hypertension with associated maternal organ dysfunction or fetal features suggesting placental dysfunction; diagnosis of hypertension in pregnancy must be based on accurate readings at home and/or in the clinic…...
ICAM2 promotes endocrine resistance via dynein-mediated OXPHOS activation in ER-positive breast cancer - Cell Death & Disease
4+ day, 9+ hour ago (125+ words) Cell Death & Disease (2026) Cite this article This work was supported by the National Natural Science Foundation of China (82273462, 82372710, 82073199, 82503431, 82503478), the "Medical Engineering Cross Research Fund" of "SJTU Star" Program (YG2026 LC13). These authors contributed equally: Si Chen, Shiyi Wu, Jiajie Hu. Department of…...
Maternal age and pregnancy-related cardiovascular complications - Nature Communications
4+ day, 9+ hour ago (892+ words) This figure demonstrates how the relative risk of major adverse cardiovascular events associated with pregnancy varies across maternal age. Source data are provided as a Source Data file. The error bars represent the 95% confidence interval. The diagonal parallel lines represent…...
Effect of obesity and endocrine therapy on the prognosis of premenopausal women with HR+HER2-breast cancer: a multi-center retrospective study - Scientific Reports
4+ day, 10+ hour ago (727+ words) Disease-free survival by BMI in premenopausal patients with HR+HER2- breast cancer. BMI, Body mass index; HR+HER2-, hormone receptor-positive and human epidermal growth factor receptor 2 negative. RCS of the relationship between BMI at diagnosis and breast cancer disease-free survival. RCS, Restricted…...
Aging promotes a RAGE-dependent increase in breast cancer metastasis - Communications Biology
1+ week, 9+ hour ago (1755+ words) Primary tumor incidence and latency in young and old hosts were similar in all 3 mouse models assayed Fig. 1 A). AT3 breast cancers grew significantly faster in aged versus young mice, (Fig. 1 A, p" A Representative co-immunofluorescence images of S100 A9 (red) and Ly6 G (green)…...
ESR1 fusion proteins in breast cancer: distinguishing oncogenic drivers from passenger events - Oncogene
1+ week, 1+ day ago (1549+ words) Oncogene (2026) Cite this article In this review, we use ESR1 fusions as a model system to examine how structural features, recurrence patterns, and functional consequences inform oncogenic potential, with the aim of clarifying general principles that distinguish driver fusions from passengers…...
Me CP2 Governs maternal hyperandrogenism-induced cortical defects and behavioral alterations via noncanonical AR-dependent regulation of Mef2c | Nature Communications
1+ week, 2+ day ago (1690+ words) So far, we have found that the effect of hyperandrogen on cortical neurogenesis is mediated through the collaborating effect of AR and Me CP2 on MEF2 C. Given the critical role of Me CP2 in this non-ARE regulatory pathway, we propose that overdosed Me…...
Extracellular vesicles from hypertrophic cardiomyocytes promote breast cancer progression | Communications Biology
2+ week, 2+ day ago (37+ words) These authors contributed equally: Weiwei Chen, Yutong Yao. Weiwei Chen, Yuquan He&Xin Hu Jilin Provincial Key Laboratory of Cancer Biology, Changchun, China Correspondence to Yuquan He or Xin Hu. Received: 28 August 2025 Accepted: 10 April 2026...
Does nocturnal hypertension reclassify maternal-fetal risk in women with white-coat hypertension? A cohort study in the second half of pregnancy - Hypertension Research
3+ week, 6+ day ago (125+ words) Additional data are available from the corresponding author on reasonable request. de la Sierra A, Redon J, Banegas JR, Segura J, Parati G, Gorostidi M, et al. Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients. Hypertension....
An assessment of measurement error when using maternal urinary phthalates as proxies for placental tissue levels in the estimation of the association of prenatal phthalates and infant anogenital distance - Journal of Exposure Science & Environmental Epidemiology
3+ week, 6+ day ago (1128+ words) Journal of Exposure Science & Environmental Epidemiology (2026)Cite this article Direct measurement of in utero phthalate exposure in placental and fetal tissues is generally not possible. Maternal urinary levels serve as proxies and may introduce measurement error, biasing health effect estimates....