10+ hour, 36+ min ago  (33+ words) Study Flowchart. (IMAGE)Eurek Alert! Schematic overview of the study design, including cohort selection, multi-omic analyses, functional experiments, signature construction, and therapeutic validation in LAR triple-negative breast cancer. Cancer Biology & Medicine...

6+ day, 13+ hour ago  (838+ words) Eurek Alert! TAPP, tetra (p-amino-phenyl) porphyrin; BPTA, 2, 5-bis(2-propynyloxy) terephthalaldehyde; DHTA, 2, 5-dihydroxyterephthalaldehyde; O-DCB, o-dichlorobenzene; Bu OH, n-butanol; HMGB1, high mobility group box 1 protein; CRT, calreticulin; DC, dendritic cell. Credit: Ming Wu, Gongli Hospital of Pudong New Area. Breast cancer remains one…...

3+ week, 6+ day ago  (399+ words) Portrait of researcher'Dr Fleur Mauritz Credit: EORTC / Fleur Mauritz Barcelona, Spain: The chances of breast cancer recurring remain very low when patients are treated with radiotherapy that is tailored to their individual risk following chemotherapy and surgery. These are the…...

1+ mon, 2+ week ago  (783+ words) Congenital heart defects (CHD) represent the most common congenital malformations globally and constitute a leading cause of neonatal mortality, with early maternal risk factors playing significant roles in their development. A comprehensive systematic review and meta-analysis by Zihan Suo and…...

2+ mon, 1+ day ago  (535+ words) UCSF study recommends that a menstrual history screening become a routine part of annual sickle cell care, and that patients connect with reproductive health specialists. Pain related to sickle cell disease (SCD) increases during menstruation, as do emergency department (ED)…...

2+ mon, 3+ week ago  (350+ words) A Purdue University team has discovered a new therapeutic target for triple-negative breast cancer. The team identified the role of the double-stranded ribonucleic acid known as'PACT, as well as proteins that play similar roles, as viable therapeutic targets. Graduate student…...

2+ mon, 4+ week ago  (292+ words) Study finds Fusobacterium nucleatum can drive DNA damage, tumor growth and metastasis, with heightened effects in cells with BRCA1 gene mutations image: Breast cell with mutant BRCA1 harboring f. nucleatum. Green is staining the bacteria. Blue stain is showing the nucleus of the…...

2+ mon, 4+ week ago  (53+ words) (IMAGE)Eurek Alert! The figure shows breast cancer cells aftertreatment with estrogen, which activatescertaintypes of super-enhancers, marked with gamma H2 AX, a marker for DNA damage. The field on the left shows untreated cells with little or no signs of DNA…...

4+ mon, 1+ week ago  (127+ words) The study finds that maternal psychological distress at 1 year after childbirth affects neurodevelopment in toddlers more strongly than prenatal distress Credit: Dr. Kenta Matsumura from the University of Toyama, Japan Overall, the study underscores the critical importance of effective screening…...

5+ mon, 1+ week ago  (1113+ words) Researchers discovered that embryos must clear maternal m RNAs to develop properly. When cleanup fails, it causes aberrant transcription and R-loop formation, which blocks DNA replication, damages the genome, and arrests development. Resolving R-loops can reverse these defects, revealing a…...