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Decoding tumor immunity: a four-step CIC-based subtyping strategy for precision immunotherapy.
7+ hour, 38+ min ago (170+ words) The current study was conducted in four major steps: (1) construction of cancer-immunity cycle (CIC)-related gene signatures and scoring the CIC activity in breast cancer patients; (2) classification of patients into CIC-based molecular subtypes according to the activity of six CIC steps;…...
High fructose during pregnancy impairs stem cell function in the fetal brain
12+ hour, 16+ min ago (520+ words) In a recent paper published in Stem Cell Reports, Hiroya Yamada's team from Fujita Health University School of Medicine, Toyoake, Japan found that the performance of adult rats in learning and memory tests was impaired when the rats had been…...
Associate Professor Liz Caldon [IMAGE] | Eurek Alert! Science News Releases
1+ mon, 3+ week ago (56+ words) Associate Professor Liz Caldon (IMAGE) Eurek Alert! Associate Professor Liz Caldon, lead author of the study and Lab Head at the Garvan Institute of Medical Research Credit must be given to the creator. Adaptations must be shared under the same…...
New treatment with fewer side effects reduces breast density
1+ mon, 4+ week ago (526+ words) Low doses of the investigational medicinal product endoxifen reduce breast density to the same extent as the standard treatment tamoxifen, but without causing such troublesome side effects. This is shown by a new study from Karolinska Institutet published in the…...
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2+ mon, 1+ week ago (16+ words) Timeline of core technological breakthroughs in AI-assisted breast cancer management from 2010 to 2025. Eurek Alert!...
Study Flowchart. [IMAGE] | Eurek Alert! Science News Releases
2+ mon, 1+ week ago (33+ words) Study Flowchart. (IMAGE)Eurek Alert! Schematic overview of the study design, including cohort selection, multi-omic analyses, functional experiments, signature construction, and therapeutic validation in LAR triple-negative breast cancer. Cancer Biology & Medicine...
Ferrocene-modified nanoscale covalent organic frameworks for ferroptosis-based sonodynamic therapy inhibit breast cancer and its bone metastasis
2+ mon, 2+ week ago (838+ words) Eurek Alert! TAPP, tetra (p-amino-phenyl) porphyrin; BPTA, 2, 5-bis(2-propynyloxy) terephthalaldehyde; DHTA, 2, 5-dihydroxyterephthalaldehyde; O-DCB, o-dichlorobenzene; Bu OH, n-butanol; HMGB1, high mobility group box 1 protein; CRT, calreticulin; DC, dendritic cell. Credit: Ming Wu, Gongli Hospital of Pudong New Area. Breast cancer remains one…...
Breast cancer recurrence remains low, even after ten years, with radiotherapy tailored to patient's individual risk
3+ mon, 1+ week ago (399+ words) Portrait of researcher'Dr Fleur Mauritz Credit: EORTC / Fleur Mauritz Barcelona, Spain: The chances of breast cancer recurring remain very low when patients are treated with radiotherapy that is tailored to their individual risk following chemotherapy and surgery. These are the…...
Risk assessment of congenital heart defects based on maternal factors in early pregnancy'a systematic review and meta-analysis
4+ mon, 1+ hour ago (783+ words) Congenital heart defects (CHD) represent the most common congenital malformations globally and constitute a leading cause of neonatal mortality, with early maternal risk factors playing significant roles in their development. A comprehensive systematic review and meta-analysis by Zihan Suo and…...
Periods may trigger pain for many who have sickle cell disease
4+ mon, 1+ week ago (535+ words) UCSF study recommends that a menstrual history screening become a routine part of annual sickle cell care, and that patients connect with reproductive health specialists. Pain related to sickle cell disease (SCD) increases during menstruation, as do emergency department (ED)…...